CL-218,872

$200.00$4,300.00

CL-218,872 Overview

  • IUPAC Name: 1-(2-Chlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
  • Commercial Name: CL-218,872
  • Chemical Formula: C14H10Cl2N2O
  • Molar Mass: 307.15 g/mol
  • Boiling Point: Not available (due to the instability of the compound at high temperatures, exact boiling point data may not be provided).
  • Melting Point: Approximately 215–218°C (the melting point may vary depending on the purity of the sample).
  • Density: Not widely reported (estimated based on similar triazole compounds).
  • Storage Requirements:
    • CL-218,872 should be stored in a cool, dry place away from direct sunlight and moisture to preserve its integrity.
    • Ideally, it should be kept in an airtight container to prevent exposure to air, which could lead to oxidation or degradation.
    • The recommended storage temperature is between 4°C and 8°C to ensure stability.
    • It should not be exposed to extreme heat, as this can result in chemical breakdown or loss of potency.
  • Purity: 99.9% (typically available with high purity to ensure reliable results in research applications)
  • Reactivity:
    • CL-218,872 is relatively stable under standard storage conditions but should still be handled carefully to avoid reaction with incompatible substances.
    • It may react with strong acids, bases, or oxidizing agents, which could lead to the formation of hazardous byproducts.
    • CL-218,872 is sensitive to moisture, so it should be kept in a dry environment to prevent degradation.
    • Exposure to light or heat can also reduce its potency, so it should be kept in a dark environment to maintain its stability.
  • Safety Information:
    • General Safety: CL-218,872 is a selective agonist for the central nervous system, specifically designed for research into its anxiolytic and sedative effects. Like many chemicals in its class, it can have psychoactive properties that could lead to CNS depression, sedation, and other related effects. Its use should be restricted to research environments with appropriate safety protocols.
    • Handling: Always use personal protective equipment (PPE) such as gloves, goggles, and a lab coat when handling CL-218,872. It is recommended to work with this compound under a fume hood or in a well-ventilated area to avoid inhaling any dust or vapors.
    • Toxicity: The toxicity of CL-218,872 has not been widely studied, but like other triazole compounds, it may present risks if misused. Overexposure can cause symptoms such as drowsiness, dizziness, respiratory depression, or other serious side effects. It is crucial to follow appropriate handling and dosage guidelines to minimize risks.
    • First Aid Measures:
      • Skin contact: In case of skin contact, wash the affected area immediately with soap and water. If irritation or a rash persists, seek medical attention.
      • Eye contact: If the compound comes into contact with the eyes, rinse immediately with water for at least 15 minutes. Seek medical assistance if irritation continues or if any discomfort persists.
      • Inhalation: If inhaled, move the individual to fresh air immediately. If symptoms such as dizziness, shortness of breath, or chest pain occur, seek medical attention.
      • Ingestion: If ingested, do not induce vomiting unless directed by a healthcare professional. Seek immediate medical attention for evaluation and treatment.

CL-218,872 is a research chemical that acts as a selective central nervous system (CNS) agent, with effects that may include sedation and anxiolysis. It is used primarily in controlled laboratory settings to study its potential pharmacological properties. Handling this compound requires caution, as it can pose risks to human health if misused or mishandled. Proper storage, use of PPE, and adherence to safety protocols are essential when working with CL-218,872. As with all research chemicals, its long-term effects are not fully understood, and its use should be strictly limited to laboratory research.

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    CL-218,872: An Introduction to Its Properties and Uses

    CL-218,872 is a lesser-known benzodiazepine research chemical that has been studied for its effects on the central nervous system (CNS). Like other compounds in the benzodiazepine class, it primarily interacts with the GABA-A receptors in the brain, producing sedative, anxiolytic, and muscle-relaxing effects. Research into CL-218,872 provides valuable insights into how benzodiazepine analogs can be fine-tuned for specific therapeutic applications, such as anxiety, insomnia, and other neurological disorders.

    Unlike common benzodiazepines like diazepam or alprazolam, CL-218,872 is still in the early stages of research and does not have widespread clinical use. However, its potential to influence GABAergic systems makes it an interesting compound for scientific exploration in the context of anxiety treatment, sleep disorders, and even the development of less addictive sedative medications.


    Pharmacological Mechanism of CL-218,872

    1. Interaction with GABA-A Receptors

    Like other benzodiazepines, CL-218,872 works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter responsible for inhibiting neural activity in the brain. This interaction occurs at the GABA-A receptor, a crucial site in regulating the brain’s excitability.

    When CL-218,872 binds to these receptors, it potentiates GABA’s calming effects, leading to reduced neuronal firing. This makes the compound effective as an anxiolytic (anxiety-reducing), sedative, and muscle relaxant. Through these actions, CL-218,872 has the potential to be used for a range of therapeutic applications, from anxiety relief to sleep aid.


    2. Potency and Duration

    CL-218,872 is considered to be a moderately potent benzodiazepine, meaning it can produce noticeable effects at relatively low doses compared to other sedatives. The duration of its effects is still being studied, but like most benzodiazepines, it is likely to offer a prolonged sedative effect, making it useful in conditions where sustained relaxation or sleep is needed.

    The potency and relatively longer duration of action make CL-218,872 a subject of interest for researchers investigating alternative therapies for anxiety and sleep disorders, as well as its potential use in combination with other compounds to enhance therapeutic efficacy.


    Applications of CL-218,872 in Medical Research

    1. Potential for Treating Anxiety

    Anxiolytic properties are one of the most studied effects of benzodiazepines, and CL-218,872 is no exception. As a GABA-A receptor agonist, it holds promise for alleviating symptoms of anxiety, including restlessness, racing thoughts, and muscle tension. In research settings, CL-218,872 is being explored for its potential to provide anxiety relief with fewer side effects compared to traditional benzodiazepines, which often come with cognitive impairment and dependency risks.

    Researchers are particularly focused on finding compounds like CL-218,872 that may be effective in treating generalized anxiety disorder (GAD) or panic disorders without the addictive potential of more widely used drugs like diazepam or alprazolam.


    2. Sedative and Sleep Aid

    Another promising application of CL-218,872 is as a sedative or sleep aid. Benzodiazepines are commonly prescribed to manage sleep disorders, including insomnia, due to their ability to induce sleep by promoting relaxation. CL-218,872, with its potent sedative effects, is being researched for its potential to help individuals with insomnia, especially those who may not respond well to other sedatives.

    Because of its GABA-A receptor modulation, CL-218,872 could offer a reliable, short-acting solution to individuals suffering from disrupted sleep patterns, including those caused by stress or anxiety. Its ability to induce relaxation without excessive sedation may also make it a valuable tool for those seeking a more balanced, non-habit-forming treatment for insomnia.


    3. Muscle Relaxant and Anticonvulsant Properties

    Benzodiazepines are also known for their muscle-relaxing and anticonvulsant effects. CL-218,872 may hold promise in these areas as well. For individuals suffering from conditions like muscle spasms, fibromyalgia, or certain neurological disorders, muscle relaxation is an essential part of symptom management.

    The potential of CL-218,872 to reduce excessive neural activity could also make it valuable in treating seizure disorders. By inhibiting overactivity in the brain, this compound may offer another option for managing epilepsy and other conditions characterized by uncontrolled neurological firing.


    Safety and Risks of CL-218,872

    1. Dependence and Abuse Potential

    As with all benzodiazepines, one of the primary concerns with CL-218,872 is the potential for abuse and dependence. While still in the research phase, it is important to understand that even benzodiazepine analogs with a lower profile for recreational use can still pose significant risks when misused.

    Continued research is necessary to understand the addictive potential of CL-218,872 fully. Like other benzodiazepines, it may lead to tolerance, where higher doses are required to achieve the same effects, and withdrawal symptoms upon cessation. This underscores the importance of controlled usage and research to better understand how to mitigate risks.


    2. Overdose Risks

    Ingesting too much CL-218,872 can lead to dangerous side effects, including extreme sedation, respiratory depression, and even coma. As with other benzodiazepines, overdose can be life-threatening, especially if combined with other central nervous system depressants, such as alcohol or opioids.

    In research environments, it is crucial to adhere to safe dosing guidelines to prevent accidental overdoses. Researchers must be well-trained in handling this compound and be prepared with emergency protocols should an overdose occur.


    Comparing CL-218,872 with Other Benzodiazepines

    1. CL-218,872 Versus Diazepam

    Diazepam (Valium) is one of the most commonly prescribed benzodiazepines, used for anxiety, muscle spasms, and alcohol withdrawal. When compared to CL-218,872, diazepam has a longer half-life, which means its effects last longer. This can be beneficial for patients who need prolonged relief, but it also increases the risk of accumulation in the body and side effects.

    CL-218,872, on the other hand, is likely to be shorter-acting, offering a more controllable sedative effect. This could make it a better option for short-term use or acute anxiety episodes. However, as CL-218,872 is still under research, it is not yet widely used in clinical practice, unlike diazepam, which has decades of medical history supporting its safety and efficacy.


    2. CL-218,872 Versus Clobromazolam

    Clobromazolam is another benzodiazepine analog that shares many characteristics with CL-218,872, such as its GABA-A receptor activity and its sedative effects. However, Clobromazolam has a stronger reputation for being highly potent, often requiring smaller doses for similar effects. Research into CL-218,872 focuses on its safer profile, which may allow for a more balanced and controlled usage.

    While both compounds have similar uses, Clobromazolam’s potency may present a greater risk for dependence and overdose, especially when compared to CL-218,872. Researchers will need to weigh these factors when determining which compounds are most suitable for developing anxiety treatments or sleep aids.


    Conclusion

    CL-218,872 is an intriguing benzodiazepine analog that offers valuable insights into the potential therapeutic applications of GABA-A receptor modulators. Its sedative, anxiolytic, and muscle-relaxant properties make it an interesting candidate for treating anxiety, insomnia, and neurological conditions. However, as with all benzodiazepines, careful research and controlled usage are essential to understanding its safety profile and minimizing risks like dependence and overdose.

    For those interested in exploring related compounds, other research chemicals such as Clobromazolam and Avizafone HCl provide additional options for studying the effects of benzodiazepines on the CNS.

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